Is there a non-UART python transfer protocol layer to work with 512byte packets or less for BLE?

I'm on a team working on a non-profit, open-source project and we're creating a web-based configuration tool to control a piece of custom hardware on a Raspberry Pi, using the "Web Bluetooth API".

Packets over the BLE connection are limited to 512 bytes, so we seem to need a transfer protocol layer to assist communication with the Pi.

We do not want a UART implementation, as we want transmission guarantees.

Does such a transfer protocol layer exist, ideally implemented in Python?

Or is there a simple way to generate a python implementation of a transfer protocol layer, that would work with 512byte packages?

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